[Respiration Reviews]


22. At the end of glycolysis, pyruvate (3C) diffuses toward the mitochondrion. Before it enters the Krebs cycle, enzymes in the cytoplasm convert it to a 2-carbon molecule. These reactions include:

a. Coenzyme A joins the pyruvate, causing it to donate an energized electron and hydrogen ion to NAD+, making one NADH.

b. a molecule of CO2 is removed from the pyruvate - coenzyme A complex.

c. the 2-carbon molecule left over is known as Acetyl-CoA.

d. the Acetyl-CoA joins the Krebs cycle.

 

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